The Effects of Liquid IV's Multi-Ingredient Recovery Supplement on Muscle Recovery Following Exercise

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorApplied Science & Performance Institute

About this trial

The purpose of this study is to evaluate the efficacy of a multi-ingredient recovery supplement . The research will focus on strength recovery and performance maintenance assessing reductions in soreness and inflammation, as well as muscle repair and damage mitigation. By investigating these key recovery metrics, this study aims to investigate the efficacy of this supplement as a solution for active individuals seeking to optimize post-exercise recovery.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy males or females aged 18-55 years old.

Must be recreationally trained or trained/developmental as previously defined (McKay et al., 2021).

Able to read and write in English.

Cessation of current use of tart cherry extract, protein powders, essential amino acids/BCAAs, calcium fructoborate, boron, or anabolic agents for a minimum of 1 week prior to, and throughout the duration of the study.

Disqualifiers

Sedentary

Highly trained/national level or professional athlete

Known diagnosis of any cardiovascular, metabolic, musculoskeletal, endocrine, or renal disease/disorder.

Recent musculoskeletal injury (<3-months)

Trial design

Design model

Crossover

Treatments tested in this trial

  • proprietary post workout recovery supplement

    Dietary supplement

    proprietary post workout recovery supplement

  • Control placebo

    Dietary supplement

    inactive/inert placebo mix

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: proprietary post workout recovery supplementExperimental treatment 1 intervention
Group B: Control TreatmentPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Lower Body Power and Force Generation (Maximal Countermovement Jump (CMJ))

The force plate platform consists of two force plates (left \& right) containing four force sensors which measure ground reaction force. The sensors are connected to a laptop and analyzed using Mechanography GRFP Research Edition® software (version 4.2-b05.53-RES). Subjects will perform three maximal vertical CMJs on a calibrated force plate. Subjects will be instructed to stand upright on the center of the force plate with feet shoulder-width apart and hands placed on the hips. Subjects will perform a maximal effort vertical jump with proper form and instructed to land with soft knees and remain still after each jump for data capture. A 30sec rest period will be provided between each trial. Data will be used to assess maximum force output (Fmax), rate of force development (RFD), jump height (inches), and maximum power (Pmax). Force curves will be reviewed for each trial, and results averaged. This will quantify full-body mechanical power under standardized, reproducible conditions.

Time frame
Taken at baseline testing, 24 hour, 48 hour, and 72 hour.
2

Lower-Body Strength (Biodex Dynamometry)

Participants will complete isometric and isokinetic strength assessments, unilaterally on the dominant leg, of knee extension (ext) and flexion (flx) using a Biodex System 4 Pro dynamometer (Biodex Medical Systems, Shirley, NY). Proper positioning and stabilization will be ensured per manufacturer guidelines. Isometric testing - knee joint will be fixed @60° of flexion. Participants will perform 3 maximal effort ext/flx contractions, each lasting 5sec, with 5sec of rest between efforts. Highest recorded torque value across the 3 trials will be analyzed. Subjects will then complete isokinetic testing consisting of 5 maximal concentric knee ext and flx at an angular velocity of 60°/s. Full range of motion will be established prior to testing. Peak torque and average torque across all 5 repetitions will be recorded for analysis. All torque values will be gravity-corrected by the system software, and same technician will conduct all tests for consistency.

Time frame
Tested at baseline, 24 hour, 48 hour, and 72 hour.
3

Perceived Recovery Status (PRS) Likert Scale

The PRS is a composite scale directly proportional to recovery (Laurent, et al. 2011). Hence, the purpose of the scale will be to assess the participant's recovery from the previous exercise session. Subjects will be informed that having no soreness and a high feeling of recovery is a 10, while extreme soreness and low feelings of recovery, leading to limited ability to function, is defined by a range of 0-3, adequate recovery, with some ability to function, is defined by a range of 4-7, and good recovery, with the ability to function normally, is defined by a range of 8-10.

Time frame
Taken at baseline testing, 24 hours, 48 hours, and 72 hours timepoints.
4

Perceived Body Soreness Likert Scale

A 7-point likert scale will be used for lower body muscle soreness, after performing 5 air squats. The Likert scale is a validated instrument designed to assess self reported muscle soreness, measured across a 7-point scale. The scale ranges from 0 (no soreness), to 6 (unbearable soreness), and has good validity and reliability (Impellizzeri, F., et al., 2007).

Time frame
Taken at baseline testing, 24 hour, 48 hour, and 72 hour timepoints.

Secondary outcomes

1

Body Hydration Status (InBody)

Body hydration status will be assessed using multi-frequency bioelectrical impedance analysis (BIA) (InBody 770, InBody Co., Ltd., Seoul, South Korea). The InBody device uses direct segmental multi-frequency impedance (5 kHz to 1 MHz) to estimate water distribution across body compartments. Measurements will include total body water (TBW), extracellular water (ECW), and intracellular water (ICW) to evaluate fluid compartment status. BIA assessments will be conducted under standardized conditions with participants barefoot, standing upright with arms slightly abducted, and heels positioned on the footplate electrodes. Light, non-conductive clothing will be required, and all metal (e.g., jewelry, watches) are removed before testing. To minimize fluid variability, participants will avoid food, drink, and caffeine for at least 8 hours prior to testing. Measurements will be collected pre-supplementation and post-exercise/post supplement as part of the hydration analysis at baseline only.

Time frame
taken during baseline testing only - before exercise and again at ~10 minutes post treatment

Other outcomes

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