About this trial
The aim of this project is to determine the effects of performing a motor imagery task on cortical excitability during acute experimental muscle pain (induced by hypertonic saline), acute histaminergic itch (induced by histamine), and non-histaminergic itch stimulation (triggered by Cowhage). We hypothesize that motor imagery will counteract the alterations in cortical excitability observed during experimental muscle pain and both itch models.
Eligibility criteria
Qualifiers
Healthy men and women
18-60 years
Speak and understand English
Disqualifiers
Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids, or other addictive drugs
Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder (e.g., heart stroke), or psychiatric diagnoses (e.g. depression) that may affect the results
Current use of medications that may affect the trial, such as antihistamines, antipsychotics, and painkillers, as well as systemic or topical steroids
Trial design
Treatments tested in this trial
- Hypertonic Saline
- Histamine
- Cowhage
- Transcranial magnetic stimulation (TMS)