The goal of this clinical trial is to analyze the effect of Platelet Rich Plasma (PRP) Adjuvant To Type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair.
The main questions it aims to answer are:
Does the PRP Adjuvant affect type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair? Researchers will compare patient who undergo prolapse surgery with PRP adjuvant versus patient who undergo prolapse surgery without PRP adjuvant (placeebo)
Participants will:
Patient will undergo pelvic organ prolapse reconstrucion surgery and punch biopsy and injection of PRP will perform in anterior vaginal mucosa at Pubocervical area. The second biopsy will attempt in 8 weeks post operative. imunohistochemistry examination will be done to compare the type I/III Colagen Ratio, MMP-2 and MMP-9 before and after surgery.
Patients with second-degree or higher pelvic organ prolapse
Postmenopausal pelvic organ prolapse patients
Patients with pelvic organ prolapse who will undergo surgery
Willingness to participate in the study
Patients with gynecological malignancies
Patients with a history of collagen disease
Patients with blood disorders
Andalas University
Lead sponsor
Dr. M Djamil Hospital, Padang
Collaborator