The investigators hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.
Primary outcome:
To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group.
Secondary outcomes:
* To evaluate the post-culture sperm parameters between the intervention group and control group * To evaluate the IUI parameter between the intervention group and control group * To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other pregnancy outcomes such as miscarriage, multiple pregnancy, ectopic pregnancy and molar pregnancy
Patients who were eligible for IUI cycles in Assissted Reproduction Technolog unit, Prince of Wales Hospital
Female patients aged >18 years old and < 42 years old
BMI < 30 kg/m2
Concurrent administration of other agents such as prednisolone, intravenous immunoglobulin, or G-CSF
Administration of anticoagulants or NSAIDs at least 7 days before PRP infuse
Drug addiction
Untreated urinary tract infection