The Efficacy of Intravenous Amino Acids in Reducing the Occurrence of AKI After Live Donor Liver Transplant

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorInstitute of Liver and Biliary Sciences, India

About this trial

This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT. Eligible adult patients undergoing LDLT will be randomized into two groups: one receiving Continuous infusion of a L-amino acids mixture in a dose of 2 g/kg dry body weight/day (to a maximum 100 g/day) after induction of anesthesia and insertion of CVP line till 72 hours after treatment initiation, and the other receiving standard management. The primary outcome is the incidence of AKI as per KDIGO criteria within 7 days of transplant.

Eligibility criteria

Qualifiers

All LDLT Recipient

Age: > 18 years

Signed informed consent

Disqualifiers

Negative consent.

Pediatric LDLT.

ALF patient undergoing LDLT.

Patients on intermittent or continuous renal replacement therapy.

Trial design

Treatments tested in this trial

  • L-Amino acid mixture
  • Standard of care

Treatment groups

100 Participants
are divided into 2 treatment groups