About this trial
This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT. Eligible adult patients undergoing LDLT will be randomized into two groups: one receiving Continuous infusion of a L-amino acids mixture in a dose of 2 g/kg dry body weight/day (to a maximum 100 g/day) after induction of anesthesia and insertion of CVP line till 72 hours after treatment initiation, and the other receiving standard management. The primary outcome is the incidence of AKI as per KDIGO criteria within 7 days of transplant.
Eligibility criteria
Qualifiers
All LDLT Recipient
Age: > 18 years
Signed informed consent
Disqualifiers
Negative consent.
Pediatric LDLT.
ALF patient undergoing LDLT.
Patients on intermittent or continuous renal replacement therapy.
Trial design
Treatments tested in this trial
- L-Amino acid mixture
- Standard of care