This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients requiring mechanical ventilation in the medical intensive care unit.
Patients admitted to the medical intensive care unit at Department of Medicine, Siriraj Hospital
Age ≥18 years old
Receiving mechanical ventilation due to acute respiratory failure within 72 hours before enrollment (including patients receiving mechanical ventilation before ICU admission)
Patients receiving mechanical ventilation due to indications other than acute respiratory failure, such as postoperative procedures or airway protection in comatose patients
Patients receiving mechanical ventilation for >72 hours before enrollment
Patients receiving neuromuscular blocking agents prior to randomization
Patients with impaired secretion clearance or upper airway obstruction anticipating a tracheostomy