Hypoxia is the most common adverse reaction during sedation outside the operating room.Exploring novel drug combinations to reduce the incidence of hypoxia during sedation in patients undergoing transvaginal oocyte retrieval procedures enhances patient safety and lowers perioperative adverse event rates. This multicenter, prospective, randomized, controlled clinical study will compare the hypoxia incidence rate of the remimazolam-alfentanil combination against the commonly used propofol-alfentanil combination.
Subjects aged 18 to 50 years planning to undergo painless oocyte retrieval
Subjects classified as American Society of Anesthesiologists (ASA) physical status I-II
Subjects with contraindications to general anesthesia, acute or severe cardiovascular disease history, acute upper respiratory infection, chronic obstructive pulmonary disease (COPD), asthma attacks, or uncontrolled hypertension
Subjects with alcohol abuse
Subjects with severe hepatic or renal insufficiency, severe cardiovascular disease, or psychiatric disorder history
Subjects with hearing impairment preventing communication
Diansan Su
Lead sponsor
Zhejiang University
Sponsor institution