This study aims to evaluate the efficacy of Temporal Interference (TI) stimulation in treating patients with obsessive-compulsive disorder (OCD) and to explore its potential neural mechanisms using magnetic resonance imaging (MRI) and electroencephalography (EEG).
18-50 years old
Diagnosis of OCD per DSM-5
Y-BOCS score ≥20
Have a documented history of at least two adequate trials of selective serotonin reuptake inhibitors (SSRIs). If currently receiving SSRI treatment, the dosage must be stable for at least 8 weeks prior to enrollment
Any DSM-5 diagnosis other than OCD (except OCPD)
OCD symptoms too severe to complete assessments
Received electroconvulsive therapy (ECT) within the past 6 months
Received other forms of neuromodulation within the past 2 months（see Item 3 for ECT）