The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorUniversity of Mississippi Medical Center

About this trial

This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.

Eligibility criteria

Qualifiers

Adults 18-75 years old

Normal kidney function

No heart failure

BMI 25-30kg/m2

Disqualifiers

Diagnosis of chronic illness

eGFR<60mL/min/1.73m2

Pregnancy or breast feeding

History of cutaneous or allergic reaction to iodine-based products of contrast dyes

Trial design

Treatments tested in this trial

  • High protein and sodium meal

Treatment groups

60 Participants
are divided into 3 treatment groups