The genetic characterization of urothelial tumor disease has brought to light important information about the biology of the disease. The evaluation of molecular DNA markers on tumor tissue could be an approach able to provide important information on the possible aggressiveness of the disease and the sensitivity/resistance profile to drugs commonly adopted in the advanced stage. The main objective of this study is to identify specific molecular profiles from DNA capable of predicting the clinical course of the disease and the possible sensitivity/resistance of the disease to systemic treatments
None
aged > 18 years
suffering from locally advanced or metastatic urothelial neoplasia
with the availability of tumor tissue obtained during surgery on a primary tumor or metastasis or during a diagnostic biopsy.