The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorVirginia Commonwealth University

About this trial

This study is being to see if participating in breathing exercise training and practicing this training will help with Postural tachycardia syndrome (POTS). The information may help doctors to learn more about how the different parts of people's brains communicate.

Eligibility criteria

Qualifiers

Age 18-50 years

Diagnosis of POTS, orthostatic intolerance (with or without syncope), syncope, or near-syncope

Can speak and read in English

Upcoming new patient VCU Comprehensive Autonomics Center clinic visit scheduled at least 1 week in the future

Disqualifiers

Inflammatory arthritis, connective tissue or auto-immune disorder

Any chronic neurological disorder besides POTS, orthostatic intolerance (with or without syncope), syncope, or near-syncope

Patients who have already had a new patient clinic visit where they were exposed to breathing exercise education

Evidence of unstable medical disorder, such as kidney (rising creatinine, or end-stage renal failure) or liver impairment (rising AST or ALT, or end-stage with coagulopathy), poorly controlled significant cardiovascular (CHF), respiratory, endocrine (diabetes - A1c > 9 - or untreated thyroid dysfunction) or uncontrolled psychiatric illness (such as untreated depression, psychosis, etc.)

Trial design

Treatments tested in this trial

  • breathing exercise training

Treatment groups

12 Participants
are divided into 1 treatment group