The acute mortality rate of acute myocardial infarction (AMI) reduced significantly due to emergency reperfusion and subsequent treatment strategies. However, it remains a major cause of disability and death globally. Recent studies have shown that systemic inflammation is associated with infarct size and adverse clinical outcomes after myocardial infarction. Therefore, attenuating the inflammatory response may be a therapeutic target for acute coronary syndromes and improve clinical outcomes. Preclinical and clinical data indicate that vagus nerve stimulation (VNS) plays an important role in reducing the inflammatory burden and improving myocardial ischemia. However, more clinical evidence is needed to elucidate the role of VNS in patients with acute myocardial infarction and its impact on cardiovascular events. Therefore, this study aims to investigate the effect of vagal nerve modulation intervention through a prospective, randomized controlled clinical research method.
Age between 18 and 80 years old (including 18 and 80 years old).
Patients with acute myocardial infarction who have undergone revascularization of the culprit vessel within 24 hours of onset.
Willing to participate in this study and have signed the informed consent form.
Hemodynamically unstable, with cardiogenic shock, requiring medication to maintain blood pressure and heart rate.
Baseline systolic blood pressure <90 mmHg or diastolic blood pressure <40 mmHg.
Average heart rate under monitoring <50 beats per minute.
Patients with II or III degree atrioventricular (AV) block or sick sinus syndrome who have not had a permanent pacemaker implanted.