The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
ConditionAnkylosing Spondylitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-64
SponsorSaglik Bilimleri Universitesi
About this trial
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are:
Does a gluten-free diet have an effect on disease activity and functional status in patients with ankylosing spondylitis? Does a gluten-free diet have an effect on intestinal permeability and subclinical intestinal inflammation in patients with ankylosing spondylitis? The investigators will evaluate the effects of the gluten-free diet compared to a control group.
Eligibility criteria
Qualifiers
diagnosis of axial SpA defined by ASAS criteria
Adults (aged 18-64 years)
stable treatment (NSAID and/or DMARD) for at least 3 months
provide written informed consent and submit to the requirements of the study
Disqualifiers
Any diet at the time of inclusion or within 3 months prior to inclusion;
have a history of celiac disease;
have a history of Ulcerative Colitis, Crohn's Disease and Irritable Bowel Syndrom
patients with Type 1 and Type 2 Diabetes Mellitus
Trial design
Treatments tested in this trial
- Gluten Free Diet
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov