The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD
ConditionPTSD
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-64
SponsorUniversity of Alabama, Tuscaloosa
About this trial
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.
Eligibility criteria
Qualifiers
male or female sex
right-handed
age 18-64
a current diagnosis of PTSD where the index event involves interpersonal violence exposure (e.g., physical/sexual assault).
Disqualifiers
current substance use disorder (other than alcohol, nicotine, or cannabis)
acute suicidality
history of bipolar/psychotic disorder
changes to or addition of psychiatric medication in the past 4 weeks (6 weeks for fluoxetine)
Trial design
Treatments tested in this trial
- Exercise
Treatment groups
120 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov