Prader-Willi syndrome (PWS) is a rare genetic disease, with hyperappetite and severe obesity. At present, there is no effective drugs and interventions to help control the appetite of PWS patients. More and more evidence has shown that gut microbiota is closely related to obesity. Probiotics and prebiotics can improve the structure of gut microbiota, thus improve blood lipid levels and other biochemical indicators of obese people. Therefore, this study intends to explore the effectiveness and safety of probiotics and prebiotics in controlling appetite and weight gain of PWS children.
Pre-adolescent children with Prader Willi syndrome which were definitely diagnosed by gene testing.
Consistent with the diagnostic criteria for obesity.
Not participate in other research projects at present or three months before the research;
Agree to participate in the test and obtain the consent of their parents; voluntarily be the subjects and sign the informed consent form.
Losing weight in ways other than the intervention measures of this project, such as taking weight loss drugs or known drugs that cause weight change;
Use antibiotics within 1 month before the study and lasted for 3 days or more;
Use probiotics within 1 month before the study and lasted for 3 days or more;
Complicated with liver and renal insufficiency (alanine aminotransferase and serum creatinine indexes exceed 2 times the upper limit of the normal value set by the hospital);