The Krill Ageing Muscle Mechanisms (KAMM) Study

ConditionSarcopenia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-90
SponsorUniversity of Glasgow

About this trial

This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil

Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length).

Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy.

Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.

Eligibility criteria

Qualifiers

body mass index (BMI) </= 30 kg/m2

Age >/= 65 years

Capacity to consent

Living within the Glasgow area

Disqualifiers

Diabetes mellitus

Severe cardiovascular disease

Seizure disorders

Uncontrolled hypertension (>150/90mmHg)

Trial design

Treatments tested in this trial

  • Vegetable oil
  • Krill oil

Treatment groups

80 Participants
are divided into 2 treatment groups

Sponsors and collaborators