The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
The investigator hypothesize that:
* An acute increase in lactate plasma concentration will decrease cerebral glucose uptake and increase cerebral blood flow * An acute increase in lactate plasma concentration will decrease palmitate and glucose uptake in the myocardium, and increase myocardial perfusion
Age 55-75 years
Male or postmenopausal female
BMI 20-35 kg/m2
Signed informed consent form
Clinically significant heart, lung, kidney, kidney, liver, endocrine or malignant disease basedon information obtained during an initial screening visit as well as blood samples and an ECG.
Blood donation within the last 3 months
Smoking
Alcohol- or substance abuse
University of Aarhus
Lead sponsor
Aarhus University Hospital
Collaborator