The Metabolic Impact of Intermittent Carbohydrate Restriction in Individuals With Type 2 Diabetes

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-75
SponsorHvidovre University Hospital

About this trial

The primary aim of this randomized cross-over intervention study is to investigate the effect of four weeks of intermittent carbohydrate restriction (alternating between two days of normal dietary intake and two days of carbohydrate restriction to 70-90 grams) on 24-hour average sensor glucose in individuals with type 2 diabetes compared with a four-week control period with normal dietary intake.

Eligibility criteria

Qualifiers

Men or women

35-75 years old

BMI >27 kg/m2

Known type 2 diabetes in stable glucose lowering therapy (for three months) or with HbA1c >48 mmol/mol if no glucose lowering therapy

Disqualifiers

Anemia (hemoglobin <8 mmol/L for men and <7 mmol/L for women)

TSH outside reference range

Treatment with insulin, sulfonylurea, or SGLT2-inhibitors

Treatment with systemic corticosteroids

Trial design

Treatments tested in this trial

  • Dietary macronutrient composition

Treatment groups

14 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Hvidovre University Hospital

Lead sponsor

University of Copenhagen

Collaborator

Danish Research Centre for Magnetic Resonance

Collaborator