The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
ConditionPrimary Angle-Closure Glaucoma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50+
SponsorZhongnan Hospital
About this trial
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Eligibility criteria
Qualifiers
Clinically diagnosed with primary angle-closure glaucoma (PACG)
Aged ≥ 50 years, no gender restriction
Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
Disqualifiers
Secondary glaucoma
History of previous intraocular surgery
Systemic diseases that can cause abnormal ocular zonules
Other severe ocular diseases
Trial design
Treatments tested in this trial
- No Additional Experimental Intervention
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov