About this trial
This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.
Eligibility criteria
Qualifiers
male or female at age 35-85 years,
chest pain or anginal equivalent, or
abnormal electrocardiogram with a suspicion of coronary artery disease
Disqualifiers
Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
any severe-grade valvular heart disease,
left ventricular ejection fraction <40% from any known non-coronary causes,
infiltrative cardiomyopathy,
Trial design
Treatments tested in this trial
- Quantitative Myocardial Blood Flow Evaluation
- Qualitative Myocardial Blood Flow Evaluation
- Gadavist
- Vasodilator
- Blood draw for the laboratory assessment