The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-59
SponsorUniversity of Miami
About this trial
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this pattern will predict worse outcomes at 1 year follow-up.
Eligibility criteria
Qualifiers
HIV seropositivity confirmed with lab report, medical records, or HIV testing.
Between the ages of 18-39 years
Fluency in English or Spanish
Ability to provide informed consent and perform study procedures, including estimated full-scale intelligence quotient (IQ) >75 to ensure that participants are able to understand the study.
Disqualifiers
Perinatally acquired HIV infection, as early neurodevelopmental alterations and HIV legacy effects may exist in this group
Pregnancy or lactation
Current Substance Use Disorder other than cannabis or nicotine
Certified for or self-reported medical cannabis use, or intent to become certified
Trial design
Treatments tested in this trial
- MRI Study
Treatment groups
280 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Miami
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov