The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal cardiopulmonary resuscitation (ECPR) based approach versus the conventional cardiopulmonary resuscitation (CCPR) approach.
Age ≥18 and ≤ 70 years presumed or known
Witnessed OHCA
Bystander CPR provided
Presumed cardiac or unknown cause
ACLS ≥ 30 minutes before randomization
Known limitations in care or a Do Not Attempt to Resuscitate (DNAR) order
Known severe disease making 90-day survival unlikely
Known bleeding diathesis or acute or recent intracranial bleeding
General University Hospital, Prague
Lead sponsor
Karolinska Institutet
Collaborator
Heinrich-Heine University, Duesseldorf
Collaborator
University Hospital Freiburg
Collaborator
University Medical Centre Ljubljana
Collaborator
Medical University of Vienna
Collaborator
Hospital Vall d'Hebron
Collaborator
Heart Center Leipzig - University Hospital
Collaborator
Aarhus University Hospital
Collaborator
Royal Brompton & Harefield NHS Foundation Trust
Collaborator
Region Hovedstadens Apotek
Collaborator
Ludwig-Maximilians - University of Munich
Collaborator
European Clinical Research Infrastructure Network
Collaborator
Masaryk University
Collaborator
Insel Gruppe AG, University Hospital Bern
Collaborator
University Hospital, Zürich
Collaborator
University of London
Collaborator
Uniwersytet Wrocławski
Collaborator