About this trial
Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to develop new approaches to improve the body's metabolism.
Eligibility criteria
Qualifiers
None
Disqualifiers
Body mass index (BMI) greater than or equal to 40 kg/m2
History of any local or systemic infectious disease with fever or requiring antibiotic within four weeks of drug administration;
Diabetes, either previously diagnosed or hemoglobin A1c greater than or equal to 6.5%
Use of oral or parenteral corticosteroids (epidural permitted) or other medication known to cause insulin resistance in the previous 6 weeks.
Trial design
Treatments tested in this trial
- Fat biopsy
- Blood sampling
- Blood sample for DNA analysis
Treatment groups
Sponsors and collaborators
Beth Israel Deaconess Medical Center
Lead sponsor
Joslin Diabetes Center
Collaborator
Chan Zuckerberg Initiative
Collaborator