The Practicality and Utility of Measured vs Estimated GFR in adCKD
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorManchester University NHS Foundation Trust
About this trial
The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis.
The main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods.
In addition to routine care, participants will:
* undergo a brief clinical assessment * be given an injection of iohexol and asked to perform 4 finger prick blood tests over 24 hours, recording the time of each sample. Samples will be returned in person or posted back * be asked to complete a questionnaire on their experience
Eligibility criteria
Qualifiers
Adults (18 year s or older)
Able to give informed consent
Progressive chronic kidney disease predicted to start renal replacement therapy in the next 6 months OR established on dialysis (either haemodialysis or peritoneal) with residual renal function (Urine output >100ml/day)
Disqualifiers
Under 18 years
Known allergy to iodinated contrast media
Unable to perform fingerprick blood testing
Unable to comply with urine collection
Trial design
Treatments tested in this trial
- Iohexol Inj 300 MG/ML Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov