The PRO-FUTURE Project
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-5
SponsorUniversity of Campania Luigi Vanvitelli
About this trial
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:
* Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?
Eligibility criteria
Qualifiers
unilateral UPJO
0-5years of age
Disqualifiers
bilateral UPJO
previous surgical intervention on the urinary tract
bladder or lower urinary tract symptoms or malformations
nephro- or urolithiasis, vesicoureteral reflux
Trial design
Treatments tested in this trial
- Identification of Diagnostic Biomarkers
Treatment groups
85 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Campania Luigi Vanvitelli
Lead sponsor
University of Milan
Collaborator
A.O.R.N. Santobono-Pausilipon
Collaborator
University of Modena and Reggio Emilia
Collaborator
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Collaborator
Source ClinicalTrials.gov