The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Leicester

About this trial

The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, identical to the first. This will allow us to look at any changes in brain blood flow from before management of risk factors and 4 weeks after management of risk factors.

Eligibility criteria

Qualifiers

Adults aged between 18-120 years.

Diagnosis of lacunar stroke syndrome.

New diagnosis or known diagnosis of hypertension and/or diabetes.

Disqualifiers

Those who lack capacity can have a personal consultee consent to the study if they can still perform study requirements such as the sit-stand manoeuvre. Those who either cannot perform the manoeuvre or do not have a personal consultee to allow them to consent, are not able to take part.

Those with poorly controlled medical comorbidities affecting cerebral haemodynamics. (eg., heart failure).

Trial design

Treatments tested in this trial

  • Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres

Treatment groups

75 Participants
are divided into 1 treatment group

Sponsors and collaborators

University of Leicester

Lead sponsor

British Heart Foundation

Collaborator

University Hospitals, Leicester

Collaborator