The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorLanyue Zhu
About this trial
The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.
Eligibility criteria
Qualifiers
18 years old or above
Undergo non-cardiac surgery
Disqualifiers
At least one measurement of serum creatinine (SCr) was not conducted before and after the operation
End-stage renal disease (ESRD) that has received dialysis within the past year
Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)
Acute kidney injury occurred within 7 days before the operation
Trial design
Treatments tested in this trial
- Frailty status
Treatment groups
1,000 Participants
are divided into 2 treatment groupsSponsors and collaborators
Lanyue Zhu
Lead sponsor
Zhongda Hospital
Sponsor institution
Source ClinicalTrials.gov