The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).
Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.
Aged over 18
Previous H&N SCC treated with radiotherapy with or without chemotherapy
Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx
Ability to give informed consent for biological sample collection (molecular analysis study only)
Nasopharyngeal and cutaneous SCC of the H&N
Thyroid, salivary gland, and non-squamous cell H&N cancers
Presence of distant metastasis (M1) or surgically inoperable T4b tumours