The goal of this study is to determine the burden of Rhinoviruses (RVs) as a cause of acute, severe, respiratory illnesses leading to hospitalization. A community cohort of 120 children between 12 and 36 months of age will be enrolled in the first year of the study and followed (when well and sick) for 36 months to identify the circulating RVs and provide samples to establish a host nasal transcriptome differentiating clinical from subclinical RV infections. A hospitalized cohort of 450 infants and children will be enrolled during years 1 through 3 of the study and followed for the duration of their hospitalization to investigate the findings of the community cohort. An additional 100 healthy children aged 5-17 years will be enrolled for age-match comparison with the older hospitalized cohort.
Parent/legal guardian is willing and able to provide informed consent in English.
Willing to comply with all study procedures and be available for the duration of the study.
Younger Community Group: Generally healthy children 12 to 36 months of age at the time of enrollment
Older Community Group: Generally healthy children 5 to 17 years of age at the time of enrollment.
Congenital or currently acquired immunosuppressive condition or medications (e.g., congenital immunodeficiency, Leukemia, Lupus)
Congenital anomalies that might alter frequency of infection (e.g., unrepaired cleft palate, bronchial cyst, pulmonary sequestration)
Presence of tracheostomy or gastrostomy tube
Previously enrolled a different group in the study
University of Wisconsin, Madison
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator