The ROAR Study: Reactive Oxygen Species and Reproduction
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-43
SponsorUniversity of California, San Francisco
About this trial
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.
Eligibility criteria
Qualifiers
Female age 18-43 years
Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
Male partners 18 years of age or older.
Must be a registered patient at UCSF Center for Reproductive Health
Disqualifiers
Female partner age 44 or older
Planning fresh transfer (hybrid PGS cycle)
Cleavage stage biopsy
Planning to use frozen sperm
Trial design
Treatments tested in this trial
- Oxidative stress markers
Treatment groups
1,100 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov