The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorInstitut Pasteur

About this trial

This is a research study involving humans, of the interventional type with minimal risks and constraints (RIPH2). It is a multicentric, non randomized prospective study aiming to better understand the mechanisms of the response to anti-IL-23 biologics in Spondyloarthritis patients attending the rheumatology department of Cochin, Saint-Antoine, Henri-Mondor hospitals (APHP) and Maison-Blanche Hospital (Reims).

Eligibility criteria

Qualifiers

Age : Adults (>18 years)

Satisfying ASAS diagnostic criteria for SpA

Patient has active disease, defined by the presence of active synovitis, tendinitis, or dactylitis or significant inflammatory pain of the spine, judged by the examining clinician to be due to SpA.

Informed consent signed

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Blood sampling
  • synovial aspiration

Treatment groups

90 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Institut Pasteur

Lead sponsor

Janssen Biotech, Inc.

Collaborator