The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-50
SponsorBoris Quednow
About this trial
The study aims to address the neurobiological basis of cognitive impairments in chronic cocaine users by investigating the potential impact of an acute potassium channel blockade on working memory performance and other cognitive functions.
Eligibility criteria
Qualifiers
Current diagnosis of mild, moderate, or severe CoUD according to DSM-5
Minimum cocaine use of 1g/month in the last three months
Cocaine as the primary drug of consumption
Willingness to abstain from cocaine use at least 72 hours before prior to each study visit
Disqualifiers
Presence or history of severe neurological disorders or head injuries
Current diagnosis of an acute or chronic infectious disease
If applicable: pregnancy and breastfeeding
Lifetime history of any epileptic seizures
Trial design
Treatments tested in this trial
- 4-aminopyridine (4-AP)
- Placebo
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Boris Quednow
Lead sponsor
Psychiatric University Hospital, Zurich
Sponsor institution
University of Zurich
Collaborator
Source ClinicalTrials.gov