ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to determine whether probiotic treatment can significantly modulate gut microbiome composition and functionality in endometriosis patients, specifically parameters associated with the estrobolome.
adult subjects with stage III or IV endometriosis diagnosis confirmed by biopsy
Age > 35 years
Immunocompromised patients
Patients with chronic inflammatory diseases (e.g., autoimmune disorders)
Pregnancy
The Gut Microbiome Center (Centar za crijevni mikrobiom)
Lead sponsor
Clinical Hospital Centre Zagreb
Collaborator