The investigators intend to find a noninvasive method for CB modulation therapy and find a simple and convenient indicator for assessing CB activity. This study was designed to evaluate the safety and efficacy of carotid body modulation therapy in hypertensive patients by external ultrasonic micro-bubble and also identify the association between CB volume and CB activity.
Hypertensive patients for CB modulation therapy
Two or more antihypertensive medications that had been prescribed at least 50% of the manufacturer's maximum dose for at least 2 consecutive weeks before study; Patients take an angiotensin-converting enzyme inhibitor (ACEI) (or angiotensin-ⅱ receptor antagonist (ARB)) and calcium channel blocker (CCB) (or thiazide diuretic) ; Office systolic blood pressure (SBP)≥150 mmHg and <180mmHg.
Patients for CB Volume and activity evaluation Hypertension group
Primary hypertension patients agrees to take part in this study and perform CB MRI, ultrasound, CB activity tests and sign the informed consent.
Hypertensive patients for CB modulation therapy
Carotid body anatomy is not eligible for treatment: ultrasound examination before treatment fail to find carotid body at carotid artery bifurcation.
Carotid body anatomical heterotopic is difficult to select or unsuitable for ultrasound irradiation.
Carotid anatomy that does not meet treatment conditions: severe carotid stenosis or occlusion.
Jing Huang
Lead sponsor
The Second Affiliated Hospital of Chongqing Medical University
Sponsor institution
The Second Affiliated Hospital of Chongqing Medical University
Collaborator