The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorRegion Skane

About this trial

This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention. Participants are randomized 1:1 to preoperative dental screening or no screening. The primary outcome is time to first occurrence of all-cause death, redo-intervention of the index valve, or definite infective endocarditis within 2 years. The study uses registry-based follow-up to ensure complete outcome ascertainment.

Eligibility criteria

Qualifiers

Age ≥18 years

Accepted for cardiac valve intervention

Able to provide informed consent

Disqualifiers

Previous or ongoing infective endocarditis

Urgent surgery

Pain from loose tooth/teeth

Immunosuppressive therapy (excluding corticosteroids)

Trial design

Treatments tested in this trial

  • Preoperative dental screening
  • No preoperative dental screening

Treatment groups

1,300 Participants
are divided into 2 treatment groups

Sponsors and collaborators