This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.
Age 18 years or older
Ability to provide written informed consent
Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
Presence of symptoms (NRS pain score > 0 at baseline)
Pregnancy or lactation
Current orthodontic treatment
Uncontrolled diabetes mellitus (HbA1c > 7% or FPG > 130 mg/dL)
Use of anticoagulants or antiplatelet agents