Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
AgeNot listed
SponsorPeking University Third Hospital
About this trial
The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C. The main questions it aims to answer are:
* Does Vitamin C supplementation improve the ovarian reserve prediction score? * What medical problems do participants have when taking Vitamin C supplementation?
Researchers will compare Vitamin C to a placebo (a look-alike substance that contains no drug) to see if drug Vitamin C works to improve ovarian reserve in women with ovarian aging. Participants will:
* Take Vitamin C or a placebo every day for 12 months * Visit the clinic once every 4 weeks for follow-up and drug distribution. * Return the Vitamin C box at each visit. * Report any adverse effects of treatment to the doctor. * Fill out a questionnaire at each visit. * After 6 months and 12 months of intervention, take blood test and ultrasonic examination.
Eligibility criteria
Qualifiers
Regularity of menstruation changed for less than one year.
10U/L≤ FSH<25 U/L in two tests more than 4weeks aprt.
AMH < 1.1 ng/mL.
Bilateral ovarian AFC <7.
Disqualifiers
Ovarian aging caused by TUNER (X deletion) syndrome or gene mutation.
Ovarian aging caused by ovarian surgery or chemotherapy.
Patients with severe endocrine system diseases (diabetes, thyroid disease), digestive system diseases (affecting VC absorption), cardiovascular system diseases, renal insufficiency (abnormal urine, imaging diagnosis, blood, pathological analysis confirms that kidney damage does exist, or glomerular filtration rate GFR <60mL/min), nervous system diseases such as dementia and epilepsy; patients with infectious diseases such as HIV, hepatitis, tuberculosis; patients with severe autoimmune diseases.
Continuous alcohol or drug abuse (to avoid adverse reactions caused by drinking).
Trial design
Treatments tested in this trial
- Vitamin C (Ascorbic Acid)
- Vitamin C (Ascorbic Acid)
- Placebo
Treatment groups
354 Participants
are divided into 3 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov