The study is to observe the therapeutic effects and long-term follow-up after ending anti-HBV therapy with nucleos(t)ide analogs in patients with chronic hepatitis b.
Patients received anti-HBV therapy with nucleos(t)ide analogs.
Last anti-HBV therapy should continue for at least 2 years.
For HBeAg positive patients, HBV DNA should keep negative for at least 1 year after HBeAg seroconversion before the therapy ending; for HBeAg negative patients, HBV DNA should keep negative for at least 2 years before the therapy ending.
Liver cirrhosis, HCC;
Patients with other factors causing active liver diseases;
Pregnancy or lactation;
Patients with HIV infection or congenital immune deficiency diseases;