Thyroid Function and Structure in Klinefelter Syndrome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age1-80
SponsorUniversity of Roma La Sapienza
About this trial
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
Eligibility criteria
Qualifiers
Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis;
Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging;
Availability of concurrent clinical data.
Disqualifiers
Presence of other known genetic conditions or chromosomal abnormalities;
Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests;
History of previous surgery or radiotherapy on the thyroid or pituitary glands;
Current or previous T therapy (for the pre-pubertal and pubertal groups).
Trial design
Treatments tested in this trial
- Not listed
Trial groups
600 Participants
are grouped into 3 trial groupsSponsors and collaborators
Source ClinicalTrials.gov