TIS for Improving Cognitive Impairment in Schizophrenia
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorCentral South University
About this trial
This study aims to evaluate the efficacy, safety, and underlying neural mechanisms of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS). Researchers will compare active TIS to a sham control to see if TIS works to treat CIAS. Participants will receive TIS twice a day for 2 weeks. Their clinical data, including the baseline clinical symptom scale score, cognitive function, E/I imbalance index recorded by EEG, and MRI data, will be collected at baseline, at the end of the 2-week intervention, and 4 weeks after the intervention.
Eligibility criteria
Qualifiers
Age 18-50 years old;
meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5) diagnostic criteria;
the diagnosis of schizophrenia is confirmed by the Structured Clinical Interview for DSM-5 (SCID-5);
the disease duration does not exceed 8 years;
Disqualifiers
Presence of other psychiatric comorbidities, intellectual disability, obvious mood symptoms, or substance use disorders (other than caffeine and/or tobacco);
with clear drug-induced extrapyramidal reaction;
A history of seizures, meningitis, or encephalitis;
with contraindications to transcranial electrical stimulation;
Trial design
Treatments tested in this trial
- temporal interference stimulation
- Sham stimulation
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Central South University
Lead sponsor
Second Xiangya Hospital of Central South University
Sponsor institution
Source ClinicalTrials.gov