To Compare the Efficacy and Safety of Using oXiris and M100 During CRRT

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMohd Zulfakar Mazlan, MBBS

About this trial

The purpose of this study aimed to compare the efficacy of Oxiris (Baxter) and M100 filters on IL-6 as primary outcomes and other blood cell counts, blood biochemistry (serum urea, creatinine, potassium, sodium), inflammation indicators (CRP, PCT), as secondary outcomes and safety (28 days mortality as a primary outcome and coagulopathy, lifespan of filter, usage of vasopressor, clinical conditions (ventilator-free days, ICU and hospital- length of stay) as a secondary outcome), clinical conditions (ventilator-free days, ICU and hospital- length of stay), and mortality of patients with pneumonia-related AKI.

Eligibility criteria

Qualifiers

All adult patients aged>18 years old

Diagnosis of septic shock

Diagnosis of KDIGO stage 3 acute renal failure

Disqualifiers

Moribund patient or patient that is expected to die within 72 hours

Pregnancy

patient with a bleeding tendency or known allergy to heparin

Trial design

Treatments tested in this trial

  • oXiris filter
  • M100 filter

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Mohd Zulfakar Mazlan, MBBS

Lead sponsor

Universiti Sains Malaysia

Sponsor institution