This is a prospective, observational, cohort pilot study of standardize volume of aerobic exercise on changes in BDNF concentration at 4-weeks of exercise training among Parkinson disease patients.
Thirty (N=30) participants will be consecutively enrolled and assigned to 2 groups: 1) Extensive Rehabilitation Group (exercise volume: 180 METs-min/week) or 2) Intensive Rehabilitation Group (exercise volume: 1350 METs-min/week).
The primary objective is to evaluate the dose-response effects of two different rehabilitation settings, characterized by different workload (measured as energy expenditure), on blood BDNF levels.
Diagnosis of Parkinson's Disease according to the United Kingdom (UK) Parkinson's Disease Society Brain Bank
Aged between 30 and 80 years
Disease stage II-III in "ON" phase according to modified Hoehn and Yahr (H&Y)
Mini-Mental State Examination-MMSE ≥24
Diagnosis of neurological disorders not related to Parkinson's disease
Musculoskeletal diseases that could impair gait and execution of exercise program
Presence of known cardiovascular disease that can compromise the performance required by the protocol
Presence of diabetes or other metabolic and endocrine disease
Casa di Cura San Raffaele Cassino
Lead sponsor
IRCCS San Raffaele Roma
Collaborator
San Raffaele Telematic University
Collaborator
University of Rome Tor Vergata
Collaborator
University of Urbino "Carlo Bo"
Collaborator