To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Minnesota

About this trial

Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (FiO2) is set below 40% while waiting for end tidal oxygen concentration (EtO2) to fall below 40% prior to starting thermal ablation. There is no published literature describing O2 concentration within the airways (AiO2) during jet ventilation with rigid bronchoscopy. The co-investigators of this study have recently collected data on AiO2 during rigid bronchoscopy using manual low frequency jet ventilation/high frequency jet ventilation with a period of apnea. The intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the "laser mode" is activated on the Monsoon jet ventilator. Ventilation is continued during "laser mode."

Eligibility criteria

Qualifiers

Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified.

18 years or older

Need rigid bronchoscopy as pre-determined by the interventional pulmonologist

Disqualifiers

Refusal to sign consent

Pregnant patients

Hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and/or heart rate/rhythm

Respiratory instability defined as SpO2<90% with >90% supplemental oxygen.

Trial design

Treatments tested in this trial

  • No intervention

Treatment groups

No treatment groups listed

Sponsors and collaborators