Tongue-out Radiation Therapy (TORT) for the Mitigation of Radiotherapy-related Toxicities in Patients With Head and Neck Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorYvonne Mowery

About this trial

Our institution recently began incorporating a novel "tongue-out" radiation therapy (TORT) technique for patients with head and neck tumors at particular subsites (oropharynx, larynx, hypopharynx). Protruding the tongue, i.e. "tongue-out" position, induces anatomical changes that facilitate decreased radiation dose to the oral tongue and PCM. The long-term goal is to determine whether TORT results in reduced severity and faster recovery from acute treatment-related toxicities (particularly mucositis, dysphagia, and dysgeusia) and improved long-term swallowing function and taste compared to traditional "tongue-in" RT for patients with HNC.

Eligibility criteria

Qualifiers

Must have histologically or cytologically confirmed squamous cell carcinoma of the oropharynx, larynx, or hypopharynx (cT0-4, N0-3, M0-1).

Definitive RT dose is planned for the primary site

The number of metastatic lesions is ≤5

All metastatic lesions are confined to a single organ (e.g., lung)

Disqualifiers

Patients with T1-T2 N0 glottic cancer (i.e., planned to undergo RT to the larynx only)

Posterior pharyngeal wall primary tumor

Widely metastatic disease

Surgical resection of the primary tumor

Trial design

Treatments tested in this trial

  • Tongue-out radiation therapy (TORT)

Treatment groups

35 Participants
are divided into 1 treatment group

Sponsors and collaborators

Yvonne Mowery

Lead sponsor

University of Pittsburgh

Sponsor institution

Radiological Society of North America

Collaborator