Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age4+
SponsorHenry M. Jackson Foundation for the Advancement of Military Medicine
About this trial
The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.
Eligibility criteria
Qualifiers
Age 4 years old and older with a clinical diagnosis of B-cell NHL.
Must be willing to undergo phlebotomy and/or skin punch biopsy.
Must be willing to undergo whole genome sequencing, which includes return of primary and secondary findings.
Disqualifiers
Has any condition that, in the opinion of the Principal Investigator, contraindicates participation in this study. Examples of situation that may contraindicate participation include but are not limited to a) some cases of cerebral vascular accidents where an individual no longer has the capacity to make their own medical decisions and a conservator or responsible family member is not available and b) an individual has active suicidal ideation and is a danger to themselves at the time of enrollment.
Does not have access to health care and primary care clinician.
Actively undergoing induction treatment for NHL.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
300 Participants
are grouped into 3 trial groupsSponsors and collaborators
Henry M. Jackson Foundation for the Advancement of Military Medicine
Lead sponsor
Uniformed Services University of the Health Sciences
Collaborator
Murtha Cancer Center
Collaborator
Walter Reed National Military Medical Center
Collaborator
United States Naval Medical Center, Portsmouth
Collaborator
Children's Hospital Medical Center, Cincinnati
Collaborator
The American Genome Center
Collaborator
Source ClinicalTrials.gov