Trabeculectomy Versus Peripheral Iridectomy Plus Goniotomy in Advanced PACG
ConditionPrimary Angle Closure Glaucoma
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-80
SponsorSun Yat-sen University
About this trial
A multicenter, parallel, open, non-inferior randomized controlled trial is conducted to compare the effectiveness and safety of trabeculectomy and peripheral iridectomy plus goniotomy (TVG) in the treatment of advanced primary angle closure glaucoma with no or mild cataracts.
Eligibility criteria
Qualifiers
Age 45-80 years.
PAS: ≥180° range, including nasal and inferior quadrants;
IOP >21 mmHg with or without anti-glaucoma medications (the medications include the maximally tolerated medications), taken with the Goldmann applanation tonometer;
Glaucomatous optic neuropathy (cup-to-disc [C/D] ratio ≥0.7, C/D asymmetry >0.2, or rim width at the superior and inferior temporal areas <0.1 of the vertical diameters of the optic disc);
Disqualifiers
History of ocular surgery or trauma.
Retinal disease that influences the collection of ocular parameters or other types of glaucoma, including open-angle glaucoma, secondary angle-closure glaucoma, steroidal glaucoma, angle recession glaucoma, neovascular glaucoma, nanophthalmos, and pseudoexfoliation syndrome.
Monophthalmia (best-corrected visual acuity of <0.01 in the non-study eye).
An International Standardized Ratio of >3.0, for patients receiving warfarin or anticoagulant therapy before surgery.
Trial design
Treatments tested in this trial
- Trabeculectomy
- SPI+GSL+GT
Treatment groups
88 Participants
are divided into 2 treatment groupsSponsors and collaborators
Sun Yat-sen University
Lead sponsor
The Second Affiliated Hospital of Harbin Medical University
Collaborator
First Hospital of Shijiazhuang City
Collaborator
West China Hospital
Collaborator
Chongqing Medical University
Collaborator
Handan City Eye Hospital
Collaborator
People's Hospital of Chongqing
Collaborator
Source ClinicalTrials.gov