Background:
\- Tuberculosis (TB) is an infectious disease that affects numerous people worldwide. Researchers are interested in actively recruiting individuals with TB for research and treatment studies.
Objectives:
\- To collect blood and other samples to study the natural history of tuberculosis.
Eligibility:
\- Individuals 2 years of age and older who have either active or latent tuberculosis.
Design:
* Latent TB patients: Participants will have a single study visit with a physical examination and medical history, and will provide blood samples for testing. * Active TB patients: Participants will have an initial visit with a physical examination and medical history, and will provide blood samples for testing. Participants will also provide sputum samples if required, and may have an optional skin punch biopsy to collect a sample of skin tissue for study. * Treatment for active TB will be provided as part of this protocol. * Active TB participants may be asked to return for study visits every 1-2 months while receiving treatment....
Have or are suspected to have TB infection.
Are aged 2 years or older.
Have a primary care physician, infectious diseases physician, pulmonologist, or TB specialist outside of the NIH who can provide care of his or her TB infection outside the NIH, provide directly observed therapy (DOT) if necessary, and monitor for side effects and toxicity of TB medications.
Are willing to consent to storage of specimens for future research.
Are incarcerated.
Have been ordered by a court to take TB medications.
Are unwilling or unable to comply with prescribed therapy.
Are pregnant.