Tranexamic Acid Dose and Remifentanil Titration in Septorhinoplasty
ConditionAnesthesiologist Workload
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorIstinye University
About this trial
This prospective observational cohort study aims to investigate whether the weight-based equivalent (mg/kg) of a fixed 1 g dose of tranexamic acid administered during septorhinoplasty is associated with intraoperative remifentanil titration frequency and perceived anesthesiologist workload. Although tranexamic acid is routinely given as a fixed dose, its mg/kg equivalent varies according to patient weight and may influence hemodynamic management during controlled hypotension. The primary outcome is the total number of remifentanil infusion rate adjustments during surgery. Secondary outcomes include total remifentanil consumption and postoperative anesthesiologist workload assessed using the NASA Task Load Index (NASA-TLX).
Eligibility criteria
Qualifiers
Age ≥ 18 years
Elective septorhinoplasty under general anesthesia
Intraoperative administration of fixed 1 g intravenous tranexamic acid as part of routine practice
Controlled hypotension strategy applied intraoperatively
Disqualifiers
Emergency surgery
Additional major surgical procedure performed in the same session
Known coagulation disorder
Contraindication to tranexamic acid
Trial design
Treatments tested in this trial
- NASA Task Load Index (NASA-TLX)
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov