Transcranial Doppler for Internal Carotid Artery Stenting (TCD-ICAS)
ConditionArtery Stenosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorGeneral Hospital of Shenyang Military Region
About this trial
Carotid artery stenting (CAS) prevents stroke but carries risks of perioperative cerebral embolism. Transcranial Doppler (TCD) ultrasound can detect microemboli during CAS and may offer therapeutic benefits through ultrasound-enhanced thrombolysis. Trials like SONOBUSTER and SONOBIRDIE suggest TCD reduces new brain infarctions during carotid procedures. The TCD-ICAS trial will investigate whether TCD application during and after CAS reduces perioperative cerebral emboli and improves outcomes.
Eligibility criteria
Qualifiers
Age ≥ 40 years old;
Patients with severe stenosis of the internal carotid artery;
Planned for carotid artery stent;
Modified Rankin Scale score ≤ 2;
Disqualifiers
Comorbid conditions with severe infections or severe diseases of the liver, kidney, hematopoietic system, endocrine system, etc.;
Occurrence of intracranial hemorrhage (cerebral parenchymal hemorrhage, subarachnoid hemorrhage, subdural/epidural hemorrhage) within 90 days prior to enrollment;
Severe hematological disorders or significant coagulation abnormalities;
Pregnant or breastfeeding women;
Trial design
Treatments tested in this trial
- Transcranial Doppler
Treatment groups
232 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov