This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices and smartphones will be collected to better predict treatment responses. Participants will also undergo repeat resting state functional Magnetic Resonance Imaging (rsfMRI) in order to assess neural predictors and mechanisms of treatment response.
Diagnosis of Obsessive-Compulsive Disorder (OCD) as determined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria.
Live in Southern California and be willing to attend in-person to receive repetitive Transcranial Magnetic Stimulation (rTMS) 5 times per week for 6 weeks.
Have completed a prior course of Exposure and Response Prevention (ERP) therapy (at least ten sessions)
Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD
Primary psychiatric diagnosis other than OCD
Active substance use disorder
Active suicidality
Active psychosis
Adam Frank
Lead sponsor
University of Southern California
Sponsor institution